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2b, Supplementary Figure 1c) confirming specificity of the DREADD agonist

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Mean Changes in Anthropometry and Cardiometabolic Parameters in Study 1 (Patients without Diabetes) Based on last observation carried forward method while on study drug 1 Least squares mean adjusted for treatment, country, sex, pre-diabetes status at screening, baseline BMI stratum and an interaction between pre-diabetes status at screening and BMI stratum as fixed factors, and the baseline value as covariate